Ciprofloxacin is an antibiotic, which is used to treat a wide range of bacterial infections. The mechanism of action of ciprofloxacin is to inhibit bacterial DNA gyrase and topoisomerase IV. The inhibitory action is due to the inhibition of DNA gyrase and topoisomerase IV, respectively, which leads to the formation of double-stranded breaks (DSBs). DSBs are often associated with bacterial cell death due to bacterial DNA gyrase, whereas the formation of DSBs is the result of the DNA gyrase activation by topoisomerase IV. These results are similar to those of DNA gyrase inhibition, where topoisomerase IV is inhibited by ciprofloxacin. In this study, we investigated the effect of ciprofloxacin on the DNA gyrase expression, DNA fragmentation, and the formation of DSBs in cultured human lung cancer cell. The results showed that ciprofloxacin reduced the expression of topoisomerase IV, and inhibited the formation of DSBs. In addition, ciprofloxacin treatment inhibited the expression of the topoisomerase IV gene, which may be due to the inhibition of topoisomerase IV by ciprofloxacin. In conclusion, ciprofloxacin can inhibit the expression of topoisomerase IV, which may be due to the inhibition of topoisomerase IV by ciprofloxacin.
Bacterial strains and antibiotics were obtained from the World Health Organization (WHO) (International Agency for Research on Diseases anduanidin) ().
The chemicals used in this study were of analytical grade, with purity of 98-99%. The stock solutions were prepared in different concentrations of ciprofloxacin (20 mg/mL) and the stock solutions were prepared in the same manner ().
The lung cancer cells were grown in RPMI medium (ThermoFisher) with 10% fetal bovine serum (FBS) (Becton, Dickinson and Company) and incubated at 37°C in a humidified incubator with 5% CO2. The culture medium was supplemented with antibiotics. Cell viability was assessed using a cell-frozen method. Briefly, the cells were incubated for 1.5 h with 10 µg/mL of ciprofloxacin in the presence of 0, 10, 20, 40, and 80 µg/mL of gentamicin for 48 h, and then the medium was replaced with fresh medium. Cells were collected at different time intervals by trypsin digestion, and the cell population was harvested and subjected to cell counts and flow cytometry. The ciprofloxacin concentration was measured using a CAPI plate reader (CAPI 360, Bio-Rad Laboratories Inc.).
Total RNA was extracted using the RNeasy Mini Kit (Qiagen) from cells using the RNeasy Mini Kit (Qiagen) according to the manufacturer’s instructions. The ciprofloxacin concentration was measured using a cilery NanoQPCR Kit (Qiagen) using a QSYM System (Applied Biosystems). The ciprofloxacin and gentamicin concentrations were detected by qPCR using the Fast SYBR Green Kit (Takara) with divalent cation as the initial primer and the specific reverse transcriptase (RT) primers (Applied Biosystems). The primers used for qPCR are listed in. The sequences of ciprofloxacin, gentamicin, and ciprofloxacin-regulated genes were listed in.
The qPCR validation was performed by applying the Rotor-Gene (Qiagen) and Taqman (Applied Biosystems) real-time PCR kits using the Applied Biosystems iQ Real-Time PCR Detection System (Applied Biosystems). The standard curve was prepared with the same ciprofloxacin concentrations and gentamicin concentrations used in the experiments. The concentration of ciprofloxacin was detected by the CAPI plate reader (CAPI 360, Bio-Rad Laboratories Inc.).
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How do you use theCiprofloxacin Tablets?
This medicine contains a medicine called Ciprofloxacin. It is an antibiotic medication that belongs to the fluoroquinolone class of drugs, which are used to treat infections caused by bacteria. Ciprofloxacin works by killing bacteria and preventing them from reproducing. It can also be used to treat urinary tract infections (UTIs) caused by Escherichia coli (E. coli) and other bacteria.
The Ciprofloxacin Tablets, which is available in 250 mg and 500 mg tablets, contain the following active ingredients:
This product is not intended for use by women. Please consult your doctor for exact instructions.
For information about the usage of this medicine, refer to the.
Ciprofloxacin is a member of the fluoroquinolone class of antibiotics, which are a class of antibiotics that are used to treat a wide range of infections caused by bacteria. Ciprofloxacin works by inhibiting the synthesis of bacterial DNA, which is crucial for the survival and growth of the bacteria. It does this by inhibiting the DNA synthesis of the bacteria, resulting in their death. This action of Ciprofloxacin helps to kill the bacteria and prevent them from spreading to other organisms. It also helps to control the infection.
The mechanism behind Ciprofloxacin's effectiveness is related to its ability to inhibit the DNA synthesis of the bacteria. However, some infections may respond to the use of other antibiotics, such as those used to treat urinary tract infections (UTIs) caused by Escherichia coli, which are caused by a specific strain of bacteria. Ciprofloxacin can also be used to treat other bacterial infections, such as skin infections, sexually transmitted diseases, and infections of the blood, bone marrow, and reproductive tract.
In addition to the uses for the Ciprofloxacin Tablets, Ciprofloxacin Tablets may be used in certain other situations, including for the treatment of infections caused by other bacteria. These include certain types of infections caused by bacteria resistant to the antibiotics, such as gonorrhea, chancroid, trichomoniasis, and others. When treating these conditions, doctors will often prescribe the medication under the supervision of a physician.
Ciprofloxacin is a fluoroquinolone antibiotic, which is used to treat bacterial infections. It is commonly prescribed for bacterial infections, including respiratory infections, skin infections, urinary tract infections, and infections of the blood, bone marrow, and reproductive tract. It also inhibits the replication of bacteria, which can help to prevent the bacteria from reproducing and spreading to other organisms. Ciprofloxacin Tablets can also be used to treat bacterial infections that are caused by an overgrowth of bacteria, such as urinary tract infections. These infections usually occur in young children who are at a high risk of bacterial infection.
It also inhibits the replication of bacteria, which can help to prevent the bacteria from spreading to other organisms. The use of Ciprofloxacin Tablets may also be prescribed to treat other conditions, such as those caused by an underactive gut (e.g., Crohn's disease).
Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.
May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.
Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.
Vomiting, Stomach pain, Nausea, Diarrhea
Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.
Store between 20-25°C.
Quinolones
Use on meds go (high risk)CiprofloxacinHIV Category CUse on meds (high risk)Quinolone therapy for respiratory, urinary tract and bone and joint infections:
See MedsGo for indications. Use with caution in patients with liver or kidney disease and in patients receiving mares’ or stallion’s milk.
Ciprofloxacin is used to treat bacterial infections (e.g. gonorrhea, cytomegalovirus).
Bacterial and urinary tract infections:
The safety of ciprofloxacin during pregnancy has not been established, and it is therefore not recommended to use it during pregnancy.
In clinical trials at doses up to 500 mg three times daily, three-fourths of pregnant women reported mild to moderate side effects such as headache, dizziness, vomiting, anaemia and renal problems. It is not recommended to pregnant women.
CiprofloxacinHBackground- Gabapentin- induced seizures? Purpose- QT prolongation?- OBJECT AND educators-SOCIETY-MADE-EFFECTS-umbai: OVERVIEW Gabapentin has been associated with a small increased risk of seizures. MATERIAL-METHODS-umbai: This was a prospective, randomized, double-blind, placebo-controlled study of 625 mothers- OBJECTS-OBJECTIETE-OBJECTIETE-OBJECTIETE-EFFECTS-umbai. PATIotgery. Ethical approval. Eighty per cent of the mothers received Gabapentin.What is CIPRO 5 TABLET used for?
CIPRO 5 TABLET is used in adults in the management of bacterial infections of the respiratory tract, ear and sinus, urinary tract, genital tract, gastrointestinal tract, skin and soft tissue, bone and joint, as well as anthrax inhalation exposure infections. CIPRO 5 TABLET is also used in the management of fever in patients with neutropenia-associated infection. Use of CIPRO 5 TABLET in children and adolescents is to manage lung and bronchial infections with cystic fibrosis and complicated urinary tract infections, including infections that cause pyelonephritis (a kidney infection that needs immediate medical attention). Consult your doctor before taking CIPRO 5 TABLET.IsCIPRO 5 TABLETsafe to take?
CIPRO 5 TABLET is a relatively safe drug. However, the complications are more comparable to other drugs and hence should only be strictly taken if prescribed by a doctor for your present condition in the appropriate dose, frequency, and duration as advised.
Can I skip the dose of?
No. You should complete the full course of CIPRO 5 TABLET as prescribed by your doctor. It is important that CIPRO 5 TABLET be taken at the right dose and for the right duration given. Otherwise, the symptoms can prevail and sometimes worsen.
Can the use of CIPRO 5 TABLET cause diarrhoea?
Yes, the use of CIPRO 5 TABLET can cause diarrhoea. It is an antibiotic that eliminates harmful bacteria. However, it also attacks the helpful bacteria in your stomach or intestine and causes diarrhoea. Consult your doctor if you are experiencing severe diarrhoea after taking CIPRO 5 TABLET.
Can CIPRO 5 TABLET increase the risk of muscle damage?
Yes, the use of CIPRO 5 TABLET is known to increase the risk of muscle damage, commonly in the ankle (Achilles tendon). Muscle damage can happen in people of all ages who take CIPRO 5 TABLET. Inform your doctor if you feel any kind of muscle pain while using this medicine.
What will happen if I accidentally take more of
If you have accidentally overdosed on CIPRO 5 TABLET, you may suffer from reversible kidney toxicity. In such cases, adequate hydration should be maintained. Hence, drink plenty of fluids, to avoid further complications. And consult a doctor immediately and visit the nearby hospital.
Can CIPRO 5 TABLET be given to breastfeeding mothers?
CIPRO 5 TABLET tablet is not recommended for breastfeeding mothers, as the medicine could harm the child. Consult your doctor if you are breastfeeding before you start taking this medication for infections.
Can I take CIPRO 5 TABLET for my cough and flu?
No, CIPRO 5 TABLET is an antibacterial medicine that acts only against specific kinds of bacterial infections and not against viral infections causing cough and flu. You should not self-medicate CIPRO 5 TABLET without prior consultation with a doctor. Self-prescription is dangerous and can lower the efficacy and therapeutic outcome of CIPRO 5 TABLET leading to antibiotic resistance.
You should not take CIPRO 5 TABLET if you haveMycoplasma pneumoniae, theYou should not take CIPRO 5 TABLET if you are planning to have an infection, have been infected for several months, or if you are allergic to CIPRO 5 TABLET. This medication belongs to a category of drugs called Antibiotics. Consult your doctor if you have any low blood sugar or if you have diabetes. Consult a doctor immediately if you notice any symptoms of an overgrowth of yeast in the vagina, or if the yeast becomes sensitive to antibiotics. A yeast infection occurs when a fungus grows in your mouth or your throat during your treatment with CIPRO 5 TABLET. CIPRO 5 TABLET can affect the normal growth of pregnant women. Consult your doctor before you are breastfeeding or engaging in breastfeeding as the medicine could harm the child.
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